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	Antacids	Acid Blockers	Gaviscon
APIs	Calcium Carbonate, Sodium Bicarbonate	H2RA (e.g. Ranitidine) PPI (e.g. Esomeprazole)	Sodium Alginate, Calcium Carbonate, Sodium Bicarbonate
Mode Of Action	Non-systemic Neutralises gastric acid. Doesn’t prevent reflux of stomach contents, incl bile & pepsin	Systemic Reduces production of gastric acid. Doesn’t prevent reflux of stomach contents, incl bile & pepsin	Non-systemic Dual MOA works with body’s natural defences (protective barrier + acid neutralisation). Prevents reflux of ALL stomach contents
Indication	As required	PPIs: Once daily dosing H2RAs: Twice daily dosing	As required
Sensorial	Limited soothing sensorial properties	No soothing sensorial properties	Soothing sensorial properties, esp liquid
Onset of action & Duration	Rapid Relief 2 hr duration	PPIs: 1 – 2 days to start working after 1st dose #12 - 24hr duration	Rapid relief (within 3 mins) 4 hrs duration
Pregnancy	Not indicated for pregnancy	Not suitable for pregnancy	Indicated for pregnancy

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